Puppies acquire mites from their mother in the first days of their life through direct skin contact. A small number of mites are usually considered as a normal component of the dog’s skin microbiota, but their proliferation leads to a potentially serious condition. It is a parasitic disease caused by mites of the genus Demodex. This clinical field study demonstrated that monthly administrations of afoxolaner in NexGard® or NexGard Spectra®, offered a convenient and reliable solution for the treatment of canine generalised demodicosis.ĭemodicosis is one of the most frequent skin conditions in dogs. In addition, the skin lesion severity and extent scores as well as the pruritus were all significantly lower at all post-treatment visits compared to the pre-treatment assessment. The number of mites was reduced by 87.6%, 96.5% and 98.1% on Days 28, 56 and 84, respectively. Treatments were well tolerated in all dogs and resulted in a rapid reduction of mites, with all post-treatment mite counts significantly lower than baseline. Efficacy of the treatments was assessed monthly by Demodex mite counts and physical examination with special regard to the severity and extension of skin lesions. Of the 50 dogs enrolled, 48 completed the whole study. Dogs were orally treated with afoxolaner three times at monthly intervals. MethodsĬlient-owned dogs, diagnosed positive for Demodex mites by pre-treatment skin scrapings and presenting clinical signs of generalised demodicosis were included. A multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland.
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